中英文摘要及关键词

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摘要



本论文第一部分对保护氨基酸的必要性进行系统的阐述，实验部分对组氨酸（his）α-氨基及侧链上的咪唑环加以保护。 Fmoc 策略合成过程中 ,三苯甲基(Trt)对缩合以及脱保护条件都很稳定 ,可被低浓度乙酸在稍高的温度条件下脱除 ,因而选用 Trt 封闭咪唑环上的活性官能团。选择 9-芴甲氧羰基（Fmoc）为其α-NH2 保护基。最终得到产品纯度98.8% ，收率72%。



关键词：组氨酸,保护氨基酸, 9-芴甲氧羰基, 三苯甲基


Abstract

The first part of this essay will systematically discuss the necessity of the protected amino acids. In the experimental part, the histidine (his) α-amino and side chain on the imidazole ring are to be protected. In the process of synthesis of the Fmoc strategy, condensation of trityl (Trt)and deprotection conditions are stable, which can be removed in low concentration of acetic acid in the slightly higher temperature conditions. Therefore we select Trt closed reactive functional group on the imidazole ring and 9 - fluorenyl methoxycarbonyl (Fmoc) for its alpha-NH2 protecting groups and finally will realize the 98.8% product purity and 72% yield.



Keywords: Histidine,Amino acid,Fmoc , Trity

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